{ "_id": "6a27ca4c24555f66ed541cbb", "Package": "TrialSimulator", "Type": "Package", "Title": "Clinical Trial Simulator", "Version": "1.19.0", "Description": "Simulate phase II and/or phase III clinical trials. It\nsupports various types of endpoints and adaptive strategies.\nTools for carrying out graphical testing procedure and\ncombination test under group sequential design are also\nprovided.", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "Authors@R": "person(\"Han\", \"Zhang\", , \"zhangh.ustc@gmail.com\", role = c(\"cre\", \"aut\"))", "RoxygenNote": "7.3.3", "VignetteBuilder": "knitr", "URL": "https://zhangh12.github.io/TrialSimulator/", "BugReports": "https://github.com/zhangh12/TrialSimulator/issues", "Config/testthat/edition": "3", "Repository": "https://zhangh12.r-universe.dev", "Date/Publication": "2026-06-09 03:36:37 UTC", "RemoteUrl": "https://github.com/zhangh12/trialsimulator", "RemoteRef": "HEAD", "RemoteSha": "987035d84f5c8dd98846c02cfeecdc36f8fe73b9", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-06-09 07:58:19 UTC", "User": "root" }, "Author": "Han Zhang [cre, aut]", "Maintainer": "Han Zhang ", "MD5sum": "517d974684fbd6809cf2e2deaeb72866", "_user": "zhangh12", "_type": "src", "_file": "TrialSimulator_1.19.0.tar.gz", "_fileid": "ea7b7fcb963d51823f9d8b75ed5253b197d33708904a368e565aba61a5f2f72b", "_filesize": 4296898, "_sha256": "ea7b7fcb963d51823f9d8b75ed5253b197d33708904a368e565aba61a5f2f72b", "_created": "2026-06-09T07:58:19.000Z", "_published": "2026-06-09T08:09:48.227Z", "_distro": "noble", "_jobs": [ { "job": 80275126242, "time": 219, "config": "linux-devel-arm64", "r": "4.7.0", "check": "OK", "artifact": "7501844669" }, { "job": 80275126217, "time": 235, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7501848967" }, { "job": 80275126317, "time": 263, "config": "linux-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7501859013" }, { "job": 80275126233, "time": 244, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7501851435" }, { "job": 80275126218, "time": 153, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7501871957" }, { "job": 80275126232, "time": 404, "config": "macos-oldrel-x86_64", "r": "4.5.3", "check": "OK", "artifact": "7501909682" }, { "job": 80275126251, "time": 143, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7501984655" }, { "job": 80275126301, "time": 311, "config": "macos-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7501878418" }, { "job": 80274300131, "time": 310, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7501770169" }, { "job": 80275126166, "time": 162, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7501824158" }, { "job": 80275126174, "time": 197, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7501835890" }, { "job": 80275126182, "time": 241, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "7501851387" }, { "job": 80275126186, "time": 209, "config": "windows-release", "r": "4.6.0", "check": "OK", "artifact": "7501839598" } ], "_buildurl": "https://github.com/r-universe/zhangh12/actions/runs/27192010877", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/zhangh12/trialsimulator", "_commit": { "id": "987035d84f5c8dd98846c02cfeecdc36f8fe73b9", "author": "Han Zhang ", "committer": "Han Zhang ", "message": "feat: add milestone-triggered crossover() adaptation (bump 1.19.0)\n\nAdd `trial$crossover(what, how, when = NULL, delay = 0, ...)` and the\n`crossover(trial, ...)` wrapper for a crossover decided at a milestone: at the\nearliest crossover calendar time T = get_current_time() + delay, eligible\npatients still in the trial may switch treatment, and only their post-switch\nendpoint values are altered.\n\nUnify regimens under one contract: each triplet carries an\n`earliest_crossover_calendar_time` (0 = enrollment regimen, > 0 = crossover);\nT only shifts the reference time max(T, enroll) and the switch floor. A shared\nprivate apply_regimens() helper replaces the inline enroll_patients() regimen\nloop and is reused by crossover(). The same contract now applies to every\nregimen: eligibility (>=1 endpoint open at max(T, enroll), dropout-/duration-\naware), `enroll + switch >= T` validation, and a post-switch mask on how()\n(changing a pre-switch/already-observed cell is an error). Existing how()\nfunctions that rewrote pre-switch outcomes must now guard with\nifelse(... , new, original).\n\nSnapshot/reset: add_regimen() snapshots a pristine deep clone and reset_regimen()\nrestores a fresh clone (or NULL) from reset() and make_arms_snapshot(), so\ncrossover's in-run append does not accumulate across replicates.\n\nAlso: NEWS.md entry for 1.19.0; add .positai to .gitignore/.Rbuildignore.\n\nTests: tests/testthat/test-crossover.R; the test-regimen.R accel example updated\nto the post-switch idiom. Full suite green.\n", "time": 1780976197 }, "_maintainer": { "name": "Han Zhang", "email": "zhangh.ustc@gmail.com", "login": "zhangh12", "description": "", "uuid": 7952833 }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 4.1.0", "role": "Depends" }, { "package": "Rcpp", "role": "LinkingTo" }, { "package": "base64enc", "role": "Imports" }, { "package": "dplyr", "role": "Imports" }, { "package": "emmeans", "role": "Imports" }, { "package": "ggplot2", "role": "Imports" }, { "package": "gMCPLite", "role": "Imports" }, { "package": "htmltools", "role": "Imports" }, { "package": "mvtnorm", "role": "Imports" }, { "package": "R6", "role": "Imports" }, { "package": "Rcpp", "role": "Imports" }, { "package": "rlang", "role": "Imports" }, { "package": "rpact", "role": "Imports" }, { "package": "rstudioapi", "role": "Imports" }, { "package": "survival", "role": "Imports" }, { "package": "utils", "role": "Imports" }, { "package": "data.table", "role": "Suggests" }, { 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correlated endpoints" ], "created": "2025-03-16 04:47:59", "modified": "2025-09-17 01:08:13", "commits": 10 }, { "source": "responseAdaptive.Rmd", "filename": "responseAdaptive.html", "title": "Designs with Response-Adaptive Randomization", "engine": "knitr::rmarkdown", "headings": [ "Simulation Settings", "Define Data Generator of fev1", "Define fev1 Endpoints for Each Arm", "Define a Trial", "Define Milestones and Associated Actions", "Execute a Trial", "Appendix: Codes of Helper Functions" ], "created": "2025-08-09 01:53:07", "modified": "2026-03-29 21:32:05", "commits": 11 }, { "source": "doseRanging.Rmd", "filename": "doseRanging.html", "title": "Dose-Ranging Study", "engine": "knitr::rmarkdown", "headings": [ "Simulation Settings", "Define Placebo and High Dose Arms", "Define a Trial", "Define Milestones and Actions", "Execute a Trial", "Appendix: Code of Helper Function" ], "created": "2025-09-27 05:07:16", "modified": "2026-04-26 04:59:22", "commits": 7 }, { "source": 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